| DCAPI1701 |
Indacaterol Maleate |
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36. |
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| DC8914 |
Indacaterol
Featured
|
Indacaterol is a potent, orally administered ultra-long-acting β2 adrenergic receptor (ADRB2) agonist, widely recognized for its therapeutic potential in respiratory and cardiovascular conditions. By selectively activating ADRB2, indacaterol not only enhances bronchodilation but also exhibits a unique mechanism of action by inhibiting NF-κB activity in a β-arrestin2-dependent manner. This dual functionality helps mitigate lung inflammation, prevent further pulmonary damage, and improve lung function in patients with chronic obstructive pulmonary disease (COPD). Beyond its respiratory applications, indacaterol has also emerged as a valuable tool in cardiovascular disease research, offering insights into its broader therapeutic effects. Its multifaceted pharmacological profile positions indacaterol as a promising candidate for addressing complex disease mechanisms and advancing treatment strategies in both respiratory and cardiovascular fields. |
|
| DCAPI1136 |
Indapamide (Lozol) |
Indapamide (Lozol) |
|
| DC21246 |
Indimitecan |
Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor.. |
|
| DC8906 |
Indinavir
Featured
|
Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. |
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| DC4137 |
Indiplon
Featured
|
Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. |
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| DC8838 |
Indirubin
Featured
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Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. |
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| DC20984 |
Indisulam
Featured
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Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
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| DC23921 |
Indolactam V |
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively. |
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| DCAPI1311 |
Indole-3-carbinol
Featured
|
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). |
|
| DCAPI1237 |
Indomethacin (Indocid, Indocin) |
Indomethacin (Indocid, Indocin) |
|
| DC9568 |
Indoprofen |
Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies. |
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| DC20276 |
Indotecan(LMP400)
Featured
|
Indotecan(LMP400) is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity. |
|
| DC10483 |
INF39
Featured
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INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. |
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| DC21138 |
Inflachromene
Featured
|
Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. |
|
| DC9651 |
Ingenol 3-angelate
Featured
|
Ingenol 3-Angelate is a PKC(protein kinase C)activator; anti-cancer drug and an active ingredient in Euphorbia peplus. |
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| DC9653 |
Ingenol 5,20-Acetonide |
Ingenol 5,20-Acetonide (CAS 77573-43-4) |
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| DC9654 |
Ingenol 5,20-Acetonide-3-O-angelate |
Ingenol 5,20-Acetonide-3-O-angelate (CAS 87980-68-5) |
|
| DC9646 |
Ingenol
Featured
|
Ingenol is an extremely weak protein kinase C (PKC) activator. |
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| DC9652 |
Ingenol-3,4:5,20-diacetonide |
Ingenol-3,4:5,20-diacetonide (CAS 77573-44-5) |
|
| DC22212 |
RNF5 INHIBITOR INH-02
Featured
|
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1. |
|
| DC7640 |
INH1 |
INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. |
|
| DC12310 |
INH154 |
INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 200 nM and 120 nM for INH in Hela and MB468 cells. |
|
| DC21704 |
Inh2-B1 |
Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain. |
|
| DC7641 |
INH6
Featured
|
INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
|
| DCAPI1506 |
Mitiglinide Calcium |
Inhibitor of ATP-sensitive K+ channel activity in MIN 6 cells. Has also been shown to bind sulfonylurea receptors as well. |
|
| DC7487 |
Pyroxamide
Featured
|
Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. |
|
| DC7479 |
Tiplaxtinin(PAI-039)
Featured
|
Inhibitor of plasminogen activator inhibitor-1 (PAI-1) |
|
| DC7197 |
ML 161
Featured
|
Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. |
|
| DCAPI1453 |
IBANDRONATE SODIUM |
Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active and the biphosphonates are used in disorders affecting the skeleton such as metastatic disease, asteoporosis and Paget's. |
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