BETd-260 trifluoroacetate|ZBC 260;ZBC260;BETd 260 TFA

Cas No.:	2140289-21-8
Chemical Name:	4-((3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino)-7-(3,5-dimethylisoxazol-4-yl)-N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide 2,2,2-trifluoroacetate
Synonyms:	ZBC 260;ZBC260;BETd 260 TFA
SMILES:	N1C2=C(C=C(OC)C(C3=C(C)ON=C3C)=C2)C2=C(NC3N(CC)N=C(C4CC4)C=3)N=C(C(NCCCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)=O)N=C12.C(O)(=O)C(F)(F)F
Formula:	C₄₅H₄₇F₃N₁₀O₈
M.Wt:	912.928
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47585	PROTAC CDK9 ligand-1	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
DC47584	PROTAC BRD4 ligand-2	PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718.
DC47372	Bromo-C10-OBn	Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs.
DC47371	1-Bromo-6-chlorohexane	1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs.
DC47370	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC47369	Propargyl-PEG2-CH2COOH	Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
DC47319	Dovitinib-RIBOTAC	Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.
DC47213	L-Homopropargylglycine hydrochloride	L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
DC47212	Boc-bipiperidine-ethynylbenzoic acid	Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61.
DC47193	OICR-9429-N-C2-NH2	OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs.