| DC40522 |
Desmorpholinyl Quizartinib-PEG2-COOH |
Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1. PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. |
|
| DC40607 |
DBCO-C2-SulfoNHS ester |
DBCO-C2-SulfoNHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC40628 |
XZ739 |
XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis. |
|
| DC40723 |
PROTAC BRD4 Degrader-5 |
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines. |
|
| DC40840 |
6-Maleimidocaproic acid sulfo-NHS |
6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC40841 |
3-Mercaptopropionic acid NHS ester
Featured
|
3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC40842 |
Mal-amino-sulfo |
Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC40858 |
BSJ-04-132 |
BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity. |
|
| DC41044 |
PROTAC KRASG12C Degrader-LC-2 |
PROTAC KRASG12C Degrader-LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. PROTAC KRASG12C Degrader-LC-2 is composed of a covalent KRAS G12C inhibitor MRTX849, a VHL ligand and a linker. |
|
| DC41057 |
L-Azidohomoalanine hydrochloride |
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC41138 |
N-Boc-piperazine |
N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1.
|
|
| DC41141 |
endo-BCN-O-PNB |
endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC42085 |
Br-C3-methyl ester |
Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1.
|
|
| DC42099 |
Maleimide-C10-NHS ester |
Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC39826 |
Homo-PROTAC cereblon degrader 1
Featured
|
Homo-PROTAC cereblon degrader 1, is a cereblon degrader. |
|
| DC42433 |
CP5V |
CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation. |
|
| DC42434 |
PROTAC IDO1 Degrader-1 |
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells. |
|
| DC42435 |
LC-2
Featured
|
LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines. |
|
| DC43998 |
Tos-O-C4-NH-Boc |
Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204
|
|
| DC51010 |
CID 138454799
Featured
|
ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. |
|
| DC44010 |
BOC-NH-PEG2-propene |
BOC-NH-PEG2-propene is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44011 |
Propenyl-PEG3-Propenyl |
Propenyl-PEG3-Propenyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44014 |
H2N-PEG2-CH2COOtBu |
H2N-PEG2-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44016 |
Benzyl-PEG2-acid |
Benzyl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44022 |
Hydroxy-PEG4-methyl acetate |
Hydroxy-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44024 |
Boc-NH-PEG-Thiol (MW 10000) |
Boc-NH-PEG-Thiol (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC44025 |
m-PEG750-Br |
m-PEG750-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44026 |
NH2-PEG-Strt (MW 10000) |
NH2-PEG-Strt (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC44027 |
NH2-PEG-Strt (MW 3000) |
NH2-PEG-Strt (MW 3000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC44028 |
m-PEG1000-CH2COOH |
m-PEG1000-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
