Cat. No. | Product name | CAS No. |
DC12181 |
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
1950635-14-9 |
DC10932 |
HDAC6 degrader 9c
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand. |
2235382-05-3 |
DC12028 |
MDK7526(Protein degrader 1)
Featured
MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader. |
1448189-80-7 |
DC21351 |
MS4078
Featured
MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM). |
2229036-62-6 |
DC21360 |
MZ1
Featured
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4. |
1797406-69-9 |
DC20512 |
VHL ligand 1
Featured
PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.. |
1448297-52-6 |
DC11040 |
QCA570
QCA570 is a novel, highly potent efficacious BET degrader (PROTAC). |
2207569-08-0 |
DC11816 |
RapaLink-1
Featured
RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors; blocks mTOR signaling of the F2108L mTOR and M2327I mTOR drug resistant mutants; RapaLink-1 is more potent mTOR inhibitor than rapamycin. |
1887095-82-0 |
DC11584 |
SNIPER(ABL)-062
SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation. |
2140260-89-3 |
DC11749 |
THAL-SNS-032
Featured
THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). |
2139287-33-3 |
DC11579 |
VH032
Featured
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.. |
1448188-62-2 |
DC26119 |
VHL ligand 2 hydrochloride
Featured
VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. |
1948273-03-7 |
DC11002 |
NTN21277(Gefitinib-based PROTAC 3)
Featured
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. |
2230821-27-7 |
DC11001 | Foretinib-Based PROTAC 7 | 2230821-68-6 |
DC22337 |
E3 ligase Ligand 4(TC-E3 5032)
Featured
E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology. |
835616-60-9 |
DC26169 |
MS1943
Featured
MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. |
2225938-17-8 |
DC28018 |
MD-224
Featured
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent. |
2136247-12-4 |
DC28073 |
CNX-500
Featured
CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn. |
1202758-21-1 |
DC28165 |
dFKBP-1
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker. |
1799711-22-0 |
DC28314 |
Aminooxy-PEG2-azide
Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
1043426-13-6 |
DC28514 |
THP-PEG6-OH
THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
42607-87-4 |
DC28539 |
SIAIS178
SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity. |
2376047-73-1 |