PROTACs

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Cat. No.	Product Name	Field of Application
DC11064	BTK PROTAC 9	BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK.
DC11679	CCT-367766 Featured	CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1].
DC12023	dBET1 Featured	dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM.
DC21893	dBET57 Featured	dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2..
DC12022	dBET6 Featured	dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM, and has antitumor activity.
DC11589	dBRD9 Featured	dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.
DC20367	dTRIM24 Featured	dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).
DC11570	E3 Ligand-Linker Conjugate 5	E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC..
DC12249	E3 ligase Ligand 1 dihydrochloride	E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology.
DC22335	E3 ligase Ligand 1A Featured	E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer. (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL)
DC11565	E3 Ligase Ligand 2 Featured	E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
DC11571	E3 Ligase Ligand 3 Featured	E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
DC12141	E3 Ligase Ligand-Linker Conjugates 22 Featured	E3 Ligase Ligand-Linker Conjugates 22 incorporates an E3 ligase ligand and a linker, can be used for the treatment of EZH2-mediated cancer.
DC12092	E3 Ligase Ligand-Linker Conjugates 23 TFA	E3 Ligase Ligand-Linker Conjugates 23 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
DC12181	E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate	E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
DC10932	HDAC6 degrader 9c	HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
DC12028	MDK7526(Protein degrader 1) Featured	MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.
DC21351	MS4078 Featured	MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).
DC21360	MZ1 Featured	MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.
DC20512	VHL ligand 1 Featured	PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation..
DC11040	QCA570	QCA570 is a novel, highly potent efficacious BET degrader (PROTAC).
DC11816	RapaLink-1 Featured	RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors; blocks mTOR signaling of the F2108L mTOR and M2327I mTOR drug resistant mutants; RapaLink-1 is more potent mTOR inhibitor than rapamycin.
DC11584	SNIPER(ABL)-062	SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
DC11749	THAL-SNS-032 Featured	THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).
DC11579	VH032 Featured	VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM..
DC26119	VHL ligand 2 hydrochloride Featured	VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader.
DC11002	NTN21277(Gefitinib-based PROTAC 3) Featured	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
DC11001	Foretinib-Based PROTAC 7
DC22337	E3 ligase Ligand 4(TC-E3 5032) Featured	E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology.
DC26169	MS1943 Featured	MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines.

PROTACs

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