Cat. No. | Product name | CAS No. |
DC10334 |
ARV-771
Featured
ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader with Kd values of 4.7, 7.6, 7.6 nM against bromodomain 2, 3 and 4, respectively. |
1949837-12-0 |
DC12024 |
ARV-825
Featured
ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. |
|
DC11566 |
BETd-260
Featured
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
2093388-62-4 |
DC11567 |
BETd-260 trifluoroacetate
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
2140289-21-8 |
DC10997 |
BRD4 degrader AT1
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. |
2098836-45-2 |
DC12380 |
BSJ-03-123
Featured
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions. |
2361493-16-3 |
DC11065 |
BTK PROTAC 10
BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells. |
|
DC11064 |
BTK PROTAC 9
BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK. |
|
DC11588 |
CC-885
Featured
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |
1010100-07-8 |
DC11679 |
CCT-367766
Featured
CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1]. |
2229856-58-8 |
DC12023 |
dBET1
Featured
dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM. |
1799711-21-9 |
DC21893 |
dBET57
Featured
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.. |
1883863-52-2 |
DC12022 |
dBET6
Featured
dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM, and has antitumor activity. |
1950634-92-0 |
DC11589 |
dBRD9
Featured
dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex. |
2170679-45-3 |
DC20367 |
dTRIM24
Featured
dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement). |
2170695-14-2 |
DC11570 |
E3 Ligand-Linker Conjugate 5
E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC.. |
2093388-69-1 |
DC12249 |
E3 ligase Ligand 1 dihydrochloride
E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. |
|
DC22335 |
E3 ligase Ligand 1A
Featured
E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer. (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) |
1948273-02-6 |
DC11565 |
E3 Ligase Ligand 2
Featured
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
5054-59-1 |
DC11571 |
E3 Ligase Ligand 3
Featured
E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology. |
1061605-21-7 |
DC12141 |
E3 Ligase Ligand-Linker Conjugates 22
Featured
E3 Ligase Ligand-Linker Conjugates 22 incorporates an E3 ligase ligand and a linker, can be used for the treatment of EZH2-mediated cancer. |
2225940-52-1 |
DC12092 |
E3 Ligase Ligand-Linker Conjugates 23 TFA
E3 Ligase Ligand-Linker Conjugates 23 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |