| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11488 | USP7-IN-4 | (R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays. |
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| DC9482 | 17-AAG Featured | 17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
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| DC11763 | ABP 1 | A nonselective inhibitor of UBL protein-activating E1 enzymes that forms covalent adducts with UBL proteins SUMO1, ubiquitin, Nedd8, ISG15, and GABARAP in the presence of ATP and E1 enzymes in vitro. |
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| DC11919 | Arimoclomol Featured | A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
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| DC11920 | Arimoclomol maleate Featured | A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
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| DC11553 | FT-827 | A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain). |
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| DC12011 | KU-32 | A novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70. |
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| DC11970 | KU675 Featured | A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively. |
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| DC11921 | Bimoclomol | A potent heat shock protein coinducer. |
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| DC11922 | BC-1382 | A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM. |
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| DC11767 | IJ-5 | A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively. |
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| DC11860 | FV-162 | A potent, orally bioavailable, irreversible proteasome inhibitor with potent antimyeloma activity (IC50<60 nM). |
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| DC11616 | KUNG94 | A potent, selective Grp94 inhibitor with IC50 of 8 nM. |
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| DC11619 | KUNG29 | A potent, selective Grp94 inhibitor with Kd of 0.2 uM. |
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| DC11618 | KUNG38 | A potent, selective Grp94 inhibitor with Kd of 0.44 uM. |
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| DC11617 | PU-H54 Featured | PU-H54 is potent, selective Grp94 inhibitor. |
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| DC11766 | UbcH5c-IN-6d | A potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM. |
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| DC11762 | ABP-A3 | ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes. |
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| DC8167 | Onalespib（AT13387,ATI13387X） Featured | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. |
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| DC5202 | Luminespib (NVP-AUY922) Featured | AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2. |
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| DC7086 | BIIB021(CNF2024) Featured | BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. |
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| DC1027 | Bortezomib (Velcade,MG-341,PS-341) Featured | Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. |
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| DC10937 | C25-140 Featured | C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity. |
|
| DC1002 | Carfilzomib (PR-171) Featured | Carfilzomib is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells,showed potent activity against COVID-19(SARS-COV-2). |
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| DC8840 | CB-5083 Featured | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . |
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| DC10146 | CC-122（Avadomide） Featured | CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL. |
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| DC10498 | CCT251236 Featured | CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. |
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| DCAPI1155 | Celastrol Featured | Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. |
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| DC8477 | VER-49009 Featured | Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. |
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| DC7390 | CUDC-305(DEBIO 0932) Featured | Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) . |
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