Proteasome/Ubiquitin

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Cat. No.	Product Name	Field of Application
DC8481	Delanzomib(CEP-18770) Featured	Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity.
DC11500	DI-591	DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.
DC10838	F1063-0967 Featured	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
DC11554	FT-671 Featured	FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
DC7320	Ganetespib(STA-9090) Featured	Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.
DC7806	Geldanamycin (NSC122750)	Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
DC12495	GNE-6640 Featured	GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
DC11555	GNE-6776 Featured	GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM .
DC12049	GSK2643943A Featured	GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM.
DC10354	HBX 19818 Featured	HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM .
DC10837	HS-10 Featured	HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C.
DC10831	HS-27 Featured	Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer.
DC10614	HSF1A Featured	HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1).
DC10344	HSP70-IN-1 Featured	HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
DC4178	NVP-HSP990 (HSP990) Featured	HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
DC10174	Iberdomide Featured	Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay.
DC11033	JG-231	JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively.
DC10852	KBU2046 Featured	KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs.
DC8247	KNK437 Featured	KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
DC9963	Kribb11 Featured	KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM).
DC7449	KW-2478 Featured	KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2
DC12332	KZR-504	KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively.
DC7610	LDN-57444 Featured	LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
DC10917	MF-094 Featured	MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM.
DC7702	MG-101 Featured	MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines.
DC7816	MG-132 Featured	MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.
DC8576	ML-240 Featured	ML-240 is am ATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM).
DC9307	ML-241 Featured	ML241 is a potent, selective, and reversible inhibitor of the AAA ATPase p97 (IC50=100 nM). It blocks p97-dependent proteasome substrate with an IC50 of 3500 nM.
DC7468	ML-323 Featured	ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
DC9994	ML-346 Featured	ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.

Proteasome/Ubiquitin

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