DC8481 |
Delanzomib(CEP-18770)
Featured
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Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity. |
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DC11500 |
DI-591 |
DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2. |
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DC10838 |
F1063-0967
Featured
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F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. |
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DC11554 |
FT-671
Featured
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FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain). |
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DC7320 |
Ganetespib(STA-9090)
Featured
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Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells. |
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DC7806 |
Geldanamycin (NSC122750) |
Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
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DC12495 |
GNE-6640
Featured
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GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM). |
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DC11555 |
GNE-6776
Featured
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GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM . |
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DC12049 |
GSK2643943A
Featured
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GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM. |
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DC10354 |
HBX 19818
Featured
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HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM . |
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DC10837 |
HS-10
Featured
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HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C. |
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DC10831 |
HS-27
Featured
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Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer. |
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DC10614 |
HSF1A
Featured
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HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). |
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DC10344 |
HSP70-IN-1
Featured
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HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. |
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DC4178 |
NVP-HSP990 (HSP990)
Featured
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HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. |
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DC10174 |
Iberdomide
Featured
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Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay. |
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DC11033 |
JG-231 |
JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively. |
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DC10852 |
KBU2046
Featured
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KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs. |
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DC8247 |
KNK437
Featured
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KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. |
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DC9963 |
Kribb11
Featured
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KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). |
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DC7449 |
KW-2478
Featured
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KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2 |
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DC12332 |
KZR-504 |
KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. |
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DC7610 |
LDN-57444
Featured
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LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
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DC10917 |
MF-094
Featured
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MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM. |
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DC7702 |
MG-101
Featured
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MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. |
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DC7816 |
MG-132
Featured
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MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM. |
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DC8576 |
ML-240
Featured
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ML-240 is am ATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM). |
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DC9307 |
ML-241
Featured
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ML241 is a potent, selective, and reversible inhibitor of the AAA ATPase p97 (IC50=100 nM). It blocks p97-dependent proteasome substrate with an IC50 of 3500 nM. |
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DC7468 |
ML-323
Featured
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ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. |
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DC9994 |
ML-346
Featured
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ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay. |
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