Proteasome/Ubiquitin

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Cat. No.	Product Name	Field of Application
DC11500	DI-591	DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.
DC10838	F1063-0967 Featured	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
DC11554	FT-671 Featured	FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
DC7320	Ganetespib(STA-9090) Featured	Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.
DC7806	Geldanamycin (NSC122750)	Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
DC12495	GNE-6640 Featured	GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).
DC11555	GNE-6776 Featured	GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM .
DC12049	GSK2643943A Featured	GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM.
DC10354	HBX 19818 Featured	HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM .
DC10837	HS-10 Featured	HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C.
DC10831	HS-27 Featured	Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer.
DC10614	HSF1A Featured	HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1).
DC10344	HSP70-IN-1 Featured	HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
DC4178	NVP-HSP990 (HSP990) Featured	HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
DC11033	JG-231	JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively.
DC10852	KBU2046 Featured	KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs.
DC8247	KNK437 Featured	KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
DC9963	Kribb11 Featured	KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM).
DC7449	KW-2478 Featured	KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2
DC12332	KZR-504	KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively.
DC7610	LDN-57444 Featured	LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
DC10917	MF-094 Featured	MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM.
DC7702	MG-101 Featured	MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines.
DC7816	MG-132 Featured	MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.
DC8576	ML-240 Featured	ML-240 is am ATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM).
DC9307	ML-241 Featured	ML241 is a potent, selective, and reversible inhibitor of the AAA ATPase p97 (IC50=100 nM). It blocks p97-dependent proteasome substrate with an IC50 of 3500 nM.
DC7468	ML-323 Featured	ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
DC9994	ML-346 Featured	ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
DC10091	ML364 Featured	ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G.
DC5086	Ixazomib(MLN2238) Featured	MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM.

Proteasome/Ubiquitin

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