| DC5176 |
Pevonedistat
Featured
|
MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. |
|
| DC5089 |
Ixazomib Citrate (MLN-9708)
Featured
|
MLN-9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome. |
|
| DC11856 |
MPC-0767 |
MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM. |
|
| DC7202 |
MPC-3100 |
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. |
|
| DC10001 |
NSC632839
Featured
|
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively. |
|
| DC5145 |
NSC697923
Featured
|
NSC697923 is a selective inhibitor of Ubc13-Uev1A |
|
| DC4118 |
NVP-BEP800
Featured
|
NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
|
| DC4243 |
ONX-0914 |
ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. |
|
| DC2010 |
Oprozomib (ONX-0912)
Featured
|
Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. |
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|
| DC8283 |
PD 150606
Featured
|
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). |
|
| DC8747 |
PD-151746
Featured
|
PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. |
|
| DC9948 |
SNX-5422(PF04929113)
Featured
|
PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). |
|
| DC9611 |
PI-1840
Featured
|
PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values >100 μM) activities of the proteasome. |
|
| DC9269 |
PRT4165（NSC-600157）
Featured
|
PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation. |
|
| DC7257 |
PYR 41
Featured
|
PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 uM, with no or little activity at E2. |
|
| DC9430 |
PYZD-4409 |
PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay).
|
|
| DC10304 |
RA190
Featured
|
RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. |
|
| DC10710 |
Skp2 Inhibitor C1(SKPin C1)
Featured
|
Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. |
|
| DC11879 |
SM253 |
SM253 (SM 253, SM-253) is a novel potent Hsp90 inhibitor that does not induce heat shock response. |
|
| DC5133 |
SNX-2112 (PF-04928473)
Featured
|
SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. |
|
| DC8319 |
Spautin 1
Featured
|
Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. |
|
| DC11633 |
TAK-243
Featured
|
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1). |
|
| DC12349 |
TAME hydrochloride |
TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1. |
|
| DC11125 |
TCH-165
Featured
|
TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. |
|
| DC10175 |
TRC051384 |
TRC051384 is a heat shock protein 70 (HSP70) inducer. |
|
| DC9431 |
TZ9
Featured
|
TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.
|
|
| DC10298 |
Ubiquitin Isopeptidase Inhibitor I, G5 |
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
|
| DC11509 |
USP25 and 28 inhibitor AZ-2 |
USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively. |
|
| DC7525 |
USP7-USP47 inhibitor |
USP7/USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 uM(USP7) and 1.0 uM(USP47). |
|
| DC8299 |
VER155008
Featured
|
VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines. |
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