| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10091 | ML364 Featured | ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G. |
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| DC5086 | Ixazomib(MLN2238) Featured | MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. |
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| DC5176 | Pevonedistat Featured | MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. |
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| DC5089 | Ixazomib Citrate (MLN-9708) Featured | MLN-9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome. |
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| DC11856 | MPC-0767 | MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM. |
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| DC7202 | MPC-3100 | MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. |
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| DC10001 | NSC632839 Featured | NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively. |
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| DC5145 | NSC697923 Featured | NSC697923 is a selective inhibitor of Ubc13-Uev1A |
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| DC4118 | NVP-BEP800 Featured | NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
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| DC4243 | ONX-0914 | ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. |
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| DC2010 | Oprozomib (ONX-0912) Featured | Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. |
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| DC8283 | PD 150606 Featured | PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). |
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| DC8747 | PD-151746 Featured | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. |
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| DC9948 | SNX-5422(PF04929113) Featured | PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). |
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| DC9611 | PI-1840 Featured | PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values >100 μM) activities of the proteasome. |
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| DC9269 | PRT4165（NSC-600157） Featured | PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation. |
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| DC7257 | PYR 41 Featured | PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 uM, with no or little activity at E2. |
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| DC9430 | PYZD-4409 | PYZD-4409 is a novel small molecule inhibitor of Ubiquitin-activating enzyme UBA1/E1 enzyme with an IC50 of 20 uM (cell-free enzymatic assay). |
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| DC10304 | RA190 Featured | RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. |
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| DC10710 | Skp2 Inhibitor C1(SKPin C1) Featured | Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. |
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| DC11879 | SM253 | SM253 (SM 253, SM-253) is a novel potent Hsp90 inhibitor that does not induce heat shock response. |
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| DC5133 | SNX-2112 (PF-04928473) Featured | SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. |
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| DC8319 | Spautin 1 Featured | Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. |
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| DC11633 | TAK-243 Featured | TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1). |
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| DC12349 | TAME hydrochloride | TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1. |
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| DC7312 | Tasisulam(LY573636) Featured | Tasisulam sodium is The sodium salt of an acyl-sulfonamide with potential antineoplastic activity. |
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| DC11125 | TCH-165 Featured | TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. |
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| DC10175 | TRC051384 | TRC051384 is a heat shock protein 70 (HSP70) inducer. |
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| DC9431 | TZ9 Featured | TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. |
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| DC10298 | Ubiquitin Isopeptidase Inhibitor I, G5 | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
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