| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC7290 | Semaxanib (SU5416) Featured | Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. |
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| DC9600 | Senicapoc Featured | Senicapoc(ICA17043) is a potent and selective Gardos channel blocker; blocked Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively. IC50 value: 11/30 nM [1] Target: Gardos channel in vitro: I |
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| DC9320 | Setiptiline (maleate) | Setiptiline is a serotonin receptor antagonist. |
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| DC9319 | Setiptiline | Setiptiline(Org-8282) is a serotonin receptor antagonist. |
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| DC11812 | SF-1126 | SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins. |
|
| DC6313 | Guadecitabine（SGI-110） Featured | SGI-110 (S-110) is a stable and potent inhibitor for DNA methylation, inhibits DNMT1 when SGI-110 is activated by phosphorylation and incorporated into DNA. |
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| DC7160 | SGI-1776 Featured | SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM; 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. |
|
| DC7294 | SGX-523 Featured | SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. |
|
| DCAPI1485 | Silodosin Featured | Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Silodosin causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it ca |
|
| DC8612 | Simeprevir(TMC-435) | Simeprevir (TMC 435350) is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). |
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| DCAPI1349 | Simvastatin (Zocor) Featured | Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. |
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| DC9690 | Sinogliatin (HMS5552, RO5305552) Featured | Sinogliatin (HMS5552, RO5305552) is a mall molecule glucokinase (GCK; GK) activator. |
|
| DC4108 | Sitaxentan sodium Featured | Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively. |
|
| DC10632 | Sitravatinib (MGCD516) Featured | Sitravatinib (MGCD516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl. |
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| DC8592 | Sivelestat (sodium salt hydrate) Featured | Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
|
| DC8500 | SKQ1(Visomitin) Featured | SKQ1 prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices. |
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| DC8049 | SNG-1153 Featured | SNG-1153 is a synthetic modulator of ER-α36 |
|
| DC7297 | SNS-032(BMS-387032) Featured | SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
|
| DC8169 | Solcitinib（GLPG0778） Featured | Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. |
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| DC8032 | Solithromycin Featured | Solithromycin is a novel ketolide antibiotic. |
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| DC11529 | Solriamfetol hydrochloride Featured | Solriamfetol hydrochloride (JZP-110, R-228060, ADX-N05, YKP-10A) is a norepinephrine-dopamine reuptake inhibitor that inhibits dopamine and norepinephrine transporter with IC50 of 2.9 and 4.4 uM, respectively. |
|
| DC2098 | Sorafenib (BAY-43-9006) Featured | Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
|
| DC8791 | Sorafenib free base (BAY-43-9006) Featured | Sorafenib(BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro. |
|
| DC7506 | Sotrastaurin Featured | Sotrastaurin(AEB-071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM; inactive to PKCζ. |
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| DC9590 | SPK-601 | SPK-601(LMV-601) is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; SPK-601 is useful antimicrobial agent. |
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| DC4131 | SR48692 Featured | SR 48692 is a neurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36 nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4 nM respectively). |
|
| DC10456 | STF-62247 Featured | STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). |
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| DCAPI1445 | strontium ranelate | Strontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Commonly used as an antiosteoporotic. |
|
| DC7302 | SU14813 Featured | SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). |
|
| DC5079 | Orantinib (TSU-68) Featured | SU6668 has greatest potency against PDGFR autophosphorylation with Ki of 8 nM, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. |
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