Cas No.: | 207671-50-9 |
SMILES: | O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15.O.[36/5] |
Formula: | C27H3O16.36/5H2O |
M.Wt: | 740.26 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | In Vivo Rutin hydrate (100 mg/kg) significantly lowers MDA levels and concomitantly increases glutathione (GSH), GSH/oxidized glutathione (GSSG) ratio, total glutathione levels and activities of GPx in the brain of rats. Rutin hydrate alone or in combination with a-tocopherol to CdCl2 intoxicated rats inhibits the declines in the levels of Ach and ChAT activity and significantly inhibited the activities of AChE. Rutin hydrate also inhibits neural apoptosis by inhibiting JNK activation in the brain of control and CdCl2 intoxicated rats and of ERK1/2 activation in the brain of CdCl2 intoxicated rats. In addition, Rutin hydrate activates mTOR/Akt in the brain of control and CdCl2 intoxicated rats. |