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6-MITC

  Cat. No.:  DC10854   Featured
Chemical Structure
4430-35-7
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Field of application
6-MITC is an inhibitor of viability of both PANC-1 and BxPC-3 cells. It also acts as an inhibitor of the expression of CSC signaling molecule SOX2.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 4430-35-7
Chemical Name: 6-Methylsulfinylhexyl Isothiocyanate
Synonyms: 6-Methylsulfinylhexyl Isothiocyanate;1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE;1-isothiocyanato-6-methylsulfinylhexane;6-Methylsulfinylhexy;(6-Isothiocyanato-hexyl)-methyl-sulfoxid;6-(methylsulfinyl)hexyl isothiocyanate;CHEMBL573428;CTK1D2491;Hexane, 1-isothiocyanato-6-(methylsulfinyl)-;Hesperin
SMILES: O=S(CCCCCCN=C=S)C
Formula: C8H15NOs2
M.Wt: 205.3408
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.
In Vivo: Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs[2].
In Vitro: Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs[2].
Cell Assay: Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs[2].
Animal Administration: Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs[2].
References: [1]. Tanaka Y, et al. 6-Methylsulfinylhexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1153-1156. [2]. Okamoto T, et al. 6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion. J Nat Med. 2014 Jan;68(1):144-53.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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