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Afoxolaner

  Cat. No.:  DC9764   Featured
Chemical Structure
1093861-60-9
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Field of application
Afoxolaner is an isoxazoline that inhibits insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), blocking pre and post synaptic transfer of chloride ions across cell membranes.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1093861-60-9
Chemical Name: Afoxolaner
Synonyms: 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide;Afoxolaner;4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide;4-(5-(3-Chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)naphthalene-1-carboxamide;Afoxolaner [USAN:INN];Afoxolaner (USAN);C26H17ClF9N3O3;4-[(5R)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-
SMILES: ClC1C([H])=C(C(F)(F)F)C([H])=C(C=1[H])C1(C(F)(F)F)C([H])([H])C(C2=C([H])C([H])=C(C(N([H])C([H])([H])C(N([H])C([H])([H])C(F)(F)F)=O)=O)C3=C([H])C([H])=C([H])C([H])=C23)=NO1
Formula: C26H17ClF9N3O3
M.Wt: 625.8701
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
In Vivo: A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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