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Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > GABA Receptor

U 93631

  Cat. No.:  DC9958   Featured
Chemical Structure
152273-12-6
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More than 5000 active chemicals with high quality for research!
Field of application
U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 152273-12-6
Synonyms: U-93631; U 93631
SMILES: O=C(C1=C2N(C=N1)C3=C(C=CC=C3)NC2(C)C)OC(C)(C)C
Formula: C17H21N3O2
M.Wt: 299.37
Purity: >98%
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.
Target: GABAA receptor
In Vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization,rather than acting as an open channel blocker. [1]
References: [1]. Dillon,GH et al.U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.Molecular Pharmacology October 1993, 44 (4) 860-865
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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