Alternate Text DC Chemicals' products qualify for U.S. tariff exemptions. We guarantee no price increases due to customs duties and maintain stable supply, continuing to deliver reliable research solutions to our American clients.
Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > GABA Receptor

Pipequaline

  Cat. No.:  DC10113   Featured
Chemical Structure
77472-98-1
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
Tel:+86-021-58447131
Get Quotation Now
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 77472-98-1
Chemical Name: PK-8165; PK8165; PK 8165
Synonyms: PK-8165; PK8165; PK 8165
SMILES: C1CNCCC1CCC2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4
Formula: C22H24N2
M.Wt: 316.44
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity.
In Vivo: Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].
In Vitro: Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC48191 Cipepofol Cipepofol (HSK3486), a sedative-hypnotic agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.
DC9958 U 93631 U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.
DC8896 Tiagabine hydrochloride Tiagabine(NO328) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
DC8099 Saclofen Saclofen is a selective GABAB antagonist.
DC10578 rac BHFF Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo.
DC10113 Pipequaline Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
DC11267 ONO-8590580 ONO-8590580 is a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models.
DC8083 NS11394 NS11394 possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
DC8642 Lorediplon Lorediplon is a new GABAA modulator Drug for treatment of insomnia.
DC10853 LAU159 LAU159 is a novelα6β3γ2 GABAA receptor inhibitor.
X
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Site Map|Privacy PolicyCopyright © 2018-2020 All Rights Reserved. Technical Support:KuuJia