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(+)-Bicuculline

  Cat. No.:  DC10625   Featured
Chemical Structure
485-49-4
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More than 5000 active chemicals with high quality for research!
Field of application
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 485-49-4
Chemical Name: Bicuculline
Synonyms: bicucullin;(+)-BICUCULINE;BICUCULLINE;D-BICUCULLINE;(+)-Bicuculline;Furo[3,4-e]-1,3-benzodioxol-8(6H)-one,6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-;2-BroMo-3-Methylpyridine;bicucculine;PLUS-BICUCULLINE;(R-(R*,S*))-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6H)-one;[ "" ];Bicculine;Bicuculline (+);C20H17NO6;Y37615DVKC;(6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one;NSC32192;Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-;(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g;d-Bicuculline;Bicuculline
SMILES: O1C(C2C3=C(C([H])=C([H])C=2[C@]1([H])[C@]1([H])C2=C([H])C4=C(C([H])=C2C([H])([H])C([H])([H])N1C([H])([H])[H])OC([H])([H])O4)OC([H])([H])O3)=O
Formula: C20H17NO6
M.Wt: 367.3521
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.
References: [1]. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct. 2014 Mar;219(2):511-26. [2]. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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