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CGP 52432

  Cat. No.:  DC10843   Featured
Chemical Structure
139667-74-6
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More than 5000 active chemicals with high quality for research!
Field of application
CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 139667-74-6
Chemical Name: CGP 52432
Synonyms: CGP 52432;3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid;[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid;Tocris-1246;CGP52432
SMILES: O=P(C(OCC)OCC)(CCCNCC1=CC=C(Cl)C(Cl)=C1)O
Formula: C15H24NO4PCl2
M.Wt: 384.23516
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
In Vivo: CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze[2]. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats[3].
In Vitro: CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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