CP-640186 hydrochloride

  Cat. No.:  DC9265   Featured
Chemical Structure
591778-70-0
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More than 5000 active chemicals with high quality for research!
Field of application
CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
Cas No.: 591778-70-0
Chemical Name: (3R)-1'-(9-Anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
Synonyms: CP-640186 (hydrochloride);CP640186 hydrochloride;(3R)-Anthracen-9-yl-[3-(morpholine-4-carbonyl)-[1,4′]bipiperidinyl-1′-yl]-methanone hydrochloride;[(3R)-1′-(9-Anthracenylcarbonyl)[1,4′-bipiperidin]-3-yl]-4-morpholinyl-methanone hydrochloride;CP640186;(R)-anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone;04L1E4J3ZT;CP 640186;(3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine;(3R)-1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine;RCP;{(3R)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin]-3-yl}(morpholin-4-yl)methanone;[(3R)-1-[1-(anthracene-9-carbonyl)piperidin-4-yl]piperidin-3-yl]-morpholin-;CP-640186 hydrochloride
SMILES: O=C([C@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(C2C3=C([H])C([H])=C([H])C([H])=C3C([H])=C3C([H])=C([H])C([H])=C([H])C=23)=O)C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
Formula: C30H35N3O3
M.Wt: 485.6172
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
References: [1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111. [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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