SG3199|SG-3199;SG 3199

Cas No.:	1595275-71-0
Chemical Name:	7-methoxy-8-((5-(((S)-7-methoxy-2-methyl-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl)oxy)-2-methyl-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one
Synonyms:	SG-3199;SG 3199
SMILES:	N12C=C(C)CC1C=NC1=CC(OCCCCCOC3C=C4C(=CC=3OC)C(=O)N3C=C(C)C[C@]3([H])C=N4)=C(OC)C=C1C2=O
Formula:	C₃₃H₃₆N₄O₆
M.Wt:	584.673
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SG3199 is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM; high-efficiently causes DNA interstrand cross-links in cancer cells; ADCT-402 (loncastuximab tesirine) is a novel CD19-targeted ADC delivering SG3199, ADCT-402 is highly potent, dose-dependent antitumor activity in several subcutaneous and disseminated human tumor models with marked superiority to comparator ADCs delivering tubulin inhibitors.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DC46937	Seco-DUBA	Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).
DC46260	DMEA-PNU-159682	DMEA-PNU-159682 (molecule D12) is a ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682.
DC46252	Azonafide-PEABA	Azonafide-PEABA is a cytotoxic drug moiety.
DC46215	Tubulysin IM-1	Tubulysin IM-1 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins.
DC45523	Seco-DUBA hydrochloride	Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.
DC44785	7-MAD-MDCPT	7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
DC44784	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC).
DC42430	Trastuzumab emtansine	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer.
DC41129	Sandramycin	Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.