APX2014

  Cat. No.:  DC11195  
Chemical Structure
1415030-17-9
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More than 5000 active chemicals with high quality for research!
Field of application
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition.
Cas No.: 1415030-17-9
Chemical Name: (E)-N-methoxy-2-((3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylene)pentanamide
Synonyms: APX 2014;APX-2014
SMILES: C(NOC)(=O)/C(=C/C1=C(OC)C(=O)C2=C(C1=O)C=CC=C2)/CCC
Formula: C18H19NO5
M.Wt: 329.352
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition; inhibits endothelial cell proliferation in HRECs and Rf/6a cells in vitro with GI50 of 0.11 and 5 uM, respectively; significantly inhibits endothelial tube formation in HRECs and Rf/6a cells in vitro, inhibits TNF-α mediated NF-κB signaling and proangiogenic target gene mRNA expression; inhibits choroidal sprouting at high nanomolar concentrations in ex vivo, blocks ocular angiogenesis in vitro and ex vivo.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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