Cas No.: | 2143467-62-1 |
Chemical Name: | N-benzyl-2-chloro-N-(1-(4-morpholinobenzoyl)azepan-4-yl)acetamide |
Synonyms: | BPK29 |
SMILES: | C(N(CC1=CC=CC=C1)C1CCCN(C(=O)C2=CC=C(N3CCOCC3)C=C2)CC1)(=O)CCl |
Formula: | C26H32ClN3O3 |
M.Wt: | 470.01 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | BPK-29 is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells; substantially engages NR0B1 (EC50<5 uM) with good overall proteomic selectivity in KEAP1-mutant NSCLCs, target a conserved cysteine C274 within the NR0B1. |