Synta-66|Synta 66;Synta 66;S66;GSK1349571A

Cas No.:	835904-51-3
Chemical Name:	N-(2',5'-Dimethoxy[1,1'-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide
Synonyms:	Synta 66;Synta 66;S66
SMILES:	C1=NC=CC(C(NC2=CC=C(C3=CC(OC)=CC=C3OC)C=C2)=O)=C1F
Formula:	C₂₀H₁₇FN₂O₃
M.Wt:	352.37
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM; does not impair other plasma membrane ion transporters; inhibits antigen-evoked Ca2+ influx in Fura-2-loaded cells at 10 uM, prevents the increase in Syk activity triggered by Ca2+ entry; reduces FcεRI-dependent Ca(2+) influx and the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα) by up to 50% at 3 uM in HLMCs.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DC44830	UK-59811 hydrochloride	UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca2+ (CaV) channel CaVAb inhibitor with an IC50 of 194 nM.
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