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BMS-22

  Cat. No.:  DC11745  
Chemical Structure
445479-97-0
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 445479-97-0
Chemical Name: 2-[(isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Synonyms: BMS 22;CCR2 inhibitor BMS 22
SMILES: C(NCC(N[C@H]1CCCC[C@H]1NC(=O)C1=CC=C(SC)C=C1)=O)(=O)C1=CC(C(F)(F)F)=CC=C1NC(NC(C)C)=O
Formula: C28H34F3N5O4S
M.Wt: 593.66
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM; displays potent functional antagonism (calcium flux IC50=18 nM and chemotaxis IC 50=1 nM).
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC41086 Vercirnon sodium Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
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