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| Cas No.: | 1869921-96-9 |
| Chemical Name: | 4-(2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole |
| Synonyms: | 4-(2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole |
| SMILES: | ClC([H])([H])C1=C(C2C([H])=C([H])C(=C([H])C=2[H])OC(F)(F)F)N=NN1C([H])([H])C([H])([H])C1C(C([H])([H])[H])=NOC=1C([H])([H])[H] |
| Formula: | C17H16ClF3N4O2 |
| M.Wt: | 400.7828 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay. |
| References: | References 1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5. View Related Products by Target DNA Methyltransferase (DNMT) |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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