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CK 666

  Cat. No.:  DC20907   Featured
Chemical Structure
442633-00-3
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More than 5000 active chemicals with high quality for research!
Field of application
CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 442633-00-3
Chemical Name: CK 666
Synonyms: CK 666;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide;CK-0944666
SMILES: O=C(C1=CC=CC=C1F)NCCC1=C(C)NC2=CC=CC=C12
Formula: C18H17FN2O
M.Wt: 296.338787794113
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].
Target: Arp2/3 complex[1]
References: [1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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