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NKH 477 hydrochloride

  Cat. No.:  DC20916   Featured
Chemical Structure
138605-00-2
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More than 5000 active chemicals with high quality for research!
Field of application
NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 138605-00-2
Chemical Name: b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylester, hydrochloride (1:1)
Synonyms: b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylester, hydrochloride (1:1);b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-1...;b-Alanine, N,N-dimethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pe;NKH 477;NKH 477,N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride;NKH477 (hydrochloride);6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl;Adehl;colforsin daropate hydrochloride;colforsindapropatehydrochloride;MKH 477;6-[3-(dimethylamino)propionyl]-forskolin;Colforsin dapropate hydrochloride;N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride
SMILES: Cl.CN(CCC(OC1C(OC(=O)C)C2(C)OC(CC(=O)C2(O)C2(C)C(CCC(C)(C)C12)O)(C)C=C)=O)C
Formula: C27H44ClNO8
M.Wt: 546.093168258667
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].
Target: Adenylate Cyclase[1]
In Vivo: NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1]. Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g[1] Dosage: 1, 2 or 3 mg/kg/day Administration: Orally; daily; Days 3 and 5 Result: Prolonged lung allograft survival in a dose dependent manner.
References: [1]. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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