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ESI-05

  Cat. No.:  DC21000   Featured
Chemical Structure
5184-64-5
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More than 5000 active chemicals with high quality for research!
Field of application
ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 5184-64-5
Chemical Name: Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Synonyms: Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene;AC1L6RWH;AC1Q6TOK;CHEMBL2313653;CTK4J4972;mesityl(4-methylphenyl) sulfone;MolPort-002-893-280;NSC116966;SureCN9001218
SMILES: CC1C=C(C)C=C(C)C=1S(C1C=CC(C)=CC=1)(=O)=O
Formula: C16H18O2S
M.Wt: 274.377923488617
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].
Target: IC50: 0.4 µM (EPAC2)[1]
References: [1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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