Sephin 1|cas 951441-04-6|DC Chemicals

Cas No.:	951441-04-6
Chemical Name:	Sephin1
SMILES:	N/C(=N/N=C/C1=CC=CC=C1Cl)/N
Formula:	C₈H₉ClN₄
M.Wt:	196.64
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Sephin 1 (NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex; prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz; safely prevents the motor, morphological, and molecular defects in mice.

References:

References 1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42. View Related Products by Target Protein Phosphatase/PTP

MSDS

COA

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2018-0101

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