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PNU-112455A

  Cat. No.:  DC21521   Featured
Chemical Structure
21886-12-4
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Field of application
PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-c-Met, IGR-1R, and ERK2..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 21886-12-4
Chemical Name: N4-(6-aminopyrimidin-4-yl)-sulfanilamide hydrochloride
Synonyms: PNU112455A
SMILES: NC1N=CN=C(NC2=CC=C(S(=O)(N)=O)C=C2)C=1
Formula: C10H12ClN5O2S
M.Wt: 301.749
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.
Description: PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively [1].
Target: CDK2:3.6 μM (Km) CDK5:3.2 μM (Km)
References: [1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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