A-420983|cas 330789-03-2|DC Chemicals

Cas No.:	330789-03-2
Chemical Name:	N-[4-[4-Amino-1-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide
Synonyms:	N-[4-[4-Amino-1-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide;A-420983
SMILES:	NC1N=CN=C2N(C3CCC(N4CCN(C)CC4)CC3)N=C(C3C=CC(NC(C4=CC5C(=CC=CC=5)N4C)=O)=C(OC)C=3)C=12
Formula:	C₃₃H₃₉N₉O₂
M.Wt:	593.72186
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A-420983 is a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.

In Vitro:

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity; prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation; does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3; dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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