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BI-4464

  Cat. No.:  DC22310   Featured
Chemical Structure
1227948-02-8
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More than 5000 active chemicals with high quality for research!
Field of application
BI-4464 (BI 4464) is a potent, highly selective, ATP competitive inhibitor of Focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1227948-02-8
Chemical Name: 3-Methoxy-N-(1-methylpiperidin-4-yl)-4-[[4-[(3-oxo-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
Synonyms: 3-Methoxy-N-(1-methylpiperidin-4-yl)-4-((4-((3-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide;BDBM134019;BCP30859;s6545;BI4464;BI 4464;US8846689, 21;3-Methoxy-N-(1-methylpiperidin-4-yl)-4-[[4-[(3-oxo-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyr;BI-4464
SMILES: FC(C1=C([H])N=C(N=C1OC1=C([H])C([H])=C([H])C2=C1C(C([H])([H])C2([H])[H])=O)N([H])C1C([H])=C([H])C(=C([H])C=1OC([H])([H])[H])C(N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=O)(F)F
Formula: C28H28F3N5O4
M.Wt: 555.5482
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC[1].
References: [1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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