Leuprorelin| CAS 53714-56-0|DC Chemicals

Cas No.:	53714-56-0
Chemical Name:	Leuprolide acetate
Synonyms:	Leuprorelin;5-OXOPRO-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5;[DES-GLY10, DLEU6, PRO9]-LH-RH, ETHYL AMIDE;[DES-GLY10, DLEU6, PRO9]-LUTEINIZING HORMONE-RELEASING HORMONE, ETHYL AMIDE;[DES-GLY10, DLEU 6, PRONHET9];(DES-GLY10,D-LEU6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LHRH;[DES-GLY10, D-LEU6, PRO-NHET9]-LH-RH (HUMAN);(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE;[DES-GLY10, D-LEU6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN;DES-GLY10,[P-LEU6]-LH-RH ETHYLAMIDE;GLP-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET;LEUPROLIDE ACETATE;LEUPROLIDE (HUMAN);LEUPRORELIN ACETATE;LH-RH LEUPROLIDE;PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET;[DES-GLY10,DLEU6, PRONHET9] LH-RH LEUPROLIDE;Leuprolide; LHRH ethylamide;5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide;Carcinil;des-Gly10 ethylamide]gonadotropin releasing hormone;Enantone;GLP-HIS-TRP-SER-TYR-DLEU-LEU-ARG-PRO-NHET: GLP-HWSY-DL-LRP-NHET;Leuplin;LEUPROPELIN;Lucrin;nghormone;pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5;Luteinizinghormone-releasing factor (pig),6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-;(D-Leu6,des-Gly-NH210)-LH-RH ethylamide;A43818;D-Leu6-des-Gly10-LH-releasing hormone ethylamide;Des-Gly10-[D-Leu6]-LH-releasing hormone ethylamide;Des-Gly10-[D-Leu6]LH-RHethylamide;1-9-Luteinizinghormone-releasing factor (swine), 6-D-leucine-9-(N-ethyl-L-prolinamide)-;Lupron SR;NSC 377526;1: PN: WO02087616 PAGE: 31 claimed protein;Lupron;Leuprolide acetate salt;Prostap;Lutrate;Onectyl;Enanton;leuprolide-acetate;DSSTox_RID_83201;DSSTox_CID_28935;DSSTox_GSID_49009;MLS000028695;RGLRXNKKBLIBQS-XNHQSDQCSA-N;Tox21_113507;SMR00005894
SMILES:	CC(O)=O.NC(N)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC2N=CNC=2)NC(=O)[C@H]3NC(=O)CC3)CC4C5=C(C=CC=C5)NC=4)C(=O)N6[C@@H](CCC6)C(=O)NCC
Formula:	C₆₁H₈₈N₁₆O₁₄
M.Wt:	1269.4502
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Leuprolide is an agonist at pituitary GnRH receptors. Target: GnRH receptorLeuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones. [1] By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. [2]

References:

[1]. Plosker GL, Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders. Drugs.1994 Dec;48(6):930-967. [2]. Leuprorelin

MSDS

COA

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2018-0101
2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC33635	DODAP	DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
DC74205	Tryptolinamide	Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
DC74198	TMX-4102	TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).