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WEB-2086

  Cat. No.:  DC22913   Featured
Chemical Structure
105219-56-5
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More than 5000 active chemicals with high quality for research!
Field of application
A potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 105219-56-5
Chemical Name: Apafant
Synonyms: Apafant;3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone;WEB 2086;[3H]-Web 2086;3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]-triazolo-[4,3-a][1,4]-diazepine-2-yl]-1-(4-morpholinyl)-1-propanone;3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4-triazolo[4,3-a][1,4]-diazepine-2-yl]-1-(4-morpholinyl)]-1-propanone;4-(2-chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)-3-propanone-1-yl]-6H-thieno-[3,2-f]-[1,2,4]triazolo[4,3-a][1,4]diazep;Apafanto;triazolodiazepine;WEB 2086BS
SMILES: O1CCN(C(CCC2=CC3C(C4=CC=CC=C4Cl)=NCC4=NN=C(C)N4C=3S2)=O)CC1
Formula: C22H22ClN5O2S
M.Wt: 455.960381984711
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Apafant (WEB 2086), a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM[1].
Target: Ki: 9.9 nM (Platelet-activating factor)[1]
References: [1]. Kato M, et al. Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. J Pharmacol Sci. 2004 Aug;95(4):435-42.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC74225 YB-537 YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
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DC74205 Tryptolinamide Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
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