NS-3623| CAS 343630-41-1|DC Chemicals

Cas No.:	343630-41-1
Chemical Name:	N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea
Synonyms:	NS 3623;NS3623
SMILES:	O=C(NC1C=C(C=CC=1)C(F)(F)F)NC2=C(C=C(Br)C=C2)C3N=NNN=3
Formula:	C₁₅H₁₀BrF₃N₆O
M.Wt:	427.185
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NS3623 is a hERG (KV11.1) and KV4.3 channel activator. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect[1][2].

References:

[1]. Hansen RS, et al. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41. [2]. Diness JG, et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009 Jan;6(1):100-6. [3]. Calloe K, et al. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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