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Zaprinast

  Cat. No.:  DC23237   Featured
Chemical Structure
37762-06-4
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More than 5000 active chemicals with high quality for research!
Field of application
Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively, also is an agonist for GPR35 (EC50=16/840 nM for rat/human GPR35).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 37762-06-4
Chemical Name: 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,3,6-dihydro-5-(2-propoxyphenyl)-
Synonyms: 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,3,6-dihydro-5-(2-propoxyphenyl)-;Zaprinast;1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one;2-(2-Propoxyphenyl)-8-azahypoxanthine;2-(2-PROPYLOXYPHENYL)-8-AZAPURIN-6-ONE;2-o-propoxyphenyl-8-azapurin-6-one;3,6-dihydro-5-(2-propoxyphenyl);8-Aza-2-(2-propoxyphenyl)-6-purinone;B 22,948;Phenylaza purinon;Potassium phosphate monobasic
SMILES: CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1
Formula: C13H13N5O2
M.Wt: 271.274621725082
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].
Target: PDE[1], GPR35[2]
References: [1]. Choi SH , et al. Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. J Neurosci Res. 2002 Feb 1;67(3):411-21. [2]. Taniguchi Y, et al. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 2006 Sep 18;580(21):5003-8. Epub 2006 Aug 17. [3]. Keswani AN , et al The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. J Cardiovasc Pharmacol Ther. 2009 Jun;14(2):116-24.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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