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Purfalcamine

  Cat. No.:  DC23274   Featured
Chemical Structure
1038620-68-6
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More than 5000 active chemicals with high quality for research!
Field of application
Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1038620-68-6
Chemical Name: [4-[[2-[(4-aminocyclohexyl)amino]-9-(3-fluorophenyl)purin-6-yl]amino]phenyl]-piperidin-1-ylmethanone
SMILES: O=C(C1=CC=C(NC2=C3N=CN(C4=CC=CC(F)=C4)C3=NC(N[C@H]5CC[C@H](N)CC5)=N2)C=C1)N6CCCCC6
Formula: C29H33FN8O
M.Wt: 528.62
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent.
References: References 1. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56. 2. Bansal A, et al. J Biol Chem. 2013 Jan 18;288(3):1590-602. 3. Gaji RY, et al. Antimicrob Agents Chemother. 2014 May;58(5):2598-607. View Related Products by Target Parasite
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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