Aplaviroc hydrochloride| CAS 461023-63-2|DC Chemicasl

Cas No.:	461023-63-2
Chemical Name:	4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid hydrochloride
Synonyms:	AK-602;GW 873140;ONO-4128;AK-602; AK602; AK 602; GW873140A; GW-873140; GW873140; GW 873140; ONO-4128; ONO 4128; ONO4128; Aplaviroc hydrochloride
SMILES:	Cl.CCCCN1C2(CCN(CC3=CC=C(C=C3)OC4=CC=C(C(O)=O)C=C4)CC2)C(=O)NC(C(O)C5CCCCC5)C1=O
Formula:	C₃₃H₄₄ClN₃O₆
M.Wt:	614.18
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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Aplaviroc HCl