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FR-901464

  Cat. No.:  DC23729   Featured
Chemical Structure
146478-72-0
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More than 5000 active chemicals with high quality for research!
Field of application
FR-901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 146478-72-0
Chemical Name: 2-Pentenamide,4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-,(2Z,4S)-
SMILES: CC(=O)O[C@@H](C)\C=C\C(=O)NC1[C@@H](C)O[C@@H](C/C=C(\C)/C=C/[C@@H]2[C@@H](O)C3(C[C@](O)(C)O2)OC3)[C@@H](C)C1
Formula: C27H41NO8
M.Wt: 507.61634
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].
In Vitro: FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1]. FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1]. FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].
References: [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11. [2]. Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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