ZZW-115| CAS 801991-87-7|DC Chemicals

Cas No.:	801991-87-7
Chemical Name:	ZZW-115(ZZW115;ZZW 115)
SMILES:	C1C=C2C(=CC=1)SC1C(=CC(=CC=1)C(F)(F)F)N2CCCN1CCN(CCN(C)C)CC1
Formula:	C₂₄H₃₁F₃N₄S
M.Wt:	464.59
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ZZW-115 (ZZW115, ZZW 115) is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation; demonstrates antitumor activity on a panel of 11 primary PDAC-derived cells and it was found to be efficient to kill the cancer cells with IC50 in the range from 0.84 μM (ANOR) to 4.93 μM (HN14), also inhibits the growth of other tumors-derived cells (IC50=0.42 μM (Hep2G cells) to 7.75 μM (SaO-2 cells)); induces pancreatic cell death by necrosis and apoptosis and inhibits the growth pancreatic xenografted tumors in vivo.

References:

References 1. Santofimia-Castaño P, et al. J Clin Invest. 2019 Mar 28;130. pii: 127223. View Related Products by Target Other Targets

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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