Tetrodotoxin citrate

  Cat. No.:  DC23911  
Chemical Structure
18660-81-6
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More than 5000 active chemicals with high quality for research!
Field of application
Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.
Cas No.: 18660-81-6
Chemical Name: 5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), [C(S),C(S),C(S),3S,4S,5R,9R,10R,11R]-
Synonyms: TTx citrate
SMILES: OC(=O)CC(CC(O)=O)(O)C(O)=O.NC1NC23[C@@H]([C@@H](O)N=1)[C@H]4[C@](CO)(O)[C@H](O[C@@](O4)(O)[C@H]3O)[C@@H]2O
Formula: C17H25N3O15
M.Wt: 511.3915
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6; Tetrodotoxin-sensitive sodium channel (Nav) family includes Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant; inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.PainPhase 3 Clinical
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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