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SPDB

  Cat. No.:  DC24125   Featured
Chemical Structure
115088-06-7
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More than 5000 active chemicals with high quality for research!
Field of application
SPDB is a disulfide chemical linker for antibody-drug conjugates (ADCs)..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 115088-06-7
Chemical Name: Butanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
SMILES: O=C(ON1C(=O)CCC1=O)CCCSSC1=CC=CC=N1
Formula: C13H14N2O4S2
M.Wt: 326.3913
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SPDB is a small fragment that can linked DM4 conjugates. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
References: [1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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