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| Cas No.: | 251945-92-3 |
| Chemical Name: | Cyclohexanol, 4-[(2-phenyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-,trans- |
| Synonyms: | Cyclohexanol, 4-[(2-phenyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-;4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol;Cyclohexanol, 4-[(2-phenyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-;SLV 320;Derenofylline;UNII-O1Q96UZ63W;4-[(4-trans-Hydroxycyclohexyl)amino]-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine;SLV-320;trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol;SC-204288;(1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol |
| SMILES: | C1=CC=C(C=C1)C2=NC3=C(C=CN3)C(=N[C@H]4CC[C@@H](CC4)O)N2 |
| Formula: | C18H20N4O |
| M.Wt: | 308.3776 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1]. |
| References: | [1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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