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AKI-7169(Aurora Kinase Inhibitor III)

  Cat. No.:  DC26118   Featured
Chemical Structure
879127-16-9
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More than 5000 active chemicals with high quality for research!
Field of application
Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 879127-16-9
Chemical Name: N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-cyclopropanecarboxamide
Synonyms: AKI-7169,AKI 7169,AKI7169
SMILES: O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2
Formula: C21H18F3N5O
M.Wt: 413.4
Purity: >98%
Description: Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures[1].
Target: Aurora A:42 nM (IC50)
References: [1]. Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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