| Cas No.: | 1421448-26-1 |
| Chemical Name: | GN44028 |
| Synonyms: | GN44028;N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;GN 44028;Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-;2-c]pyrazol-3-amine;4-benzodioxin-6-yl)-1;4-dihydroindeno[1;GN 44028,colorectal cancer,HIFs,Hypoxia,HeLa,ME23,GSCs,HIF/HIF Prolyl-Hydroxylase,inhibit,GN-44028,HCT116,cancer,heterodimerization,HIF-PH,GN44028,Hypoxia-inducible factors,PN12,Inhibitor |
| SMILES: | N1=C(NC2=CC=C3OCCOC3=C2)C2CC3=C(C=2N1)C=CC=C3 |
| Formula: | C18H15N3O2 |
| M.Wt: | 305.337 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301. |
| Description: | GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization[1]. |
| Target: | IC50: 14 nM (HIF-1)[1]. |
| References: | [1]. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301. |
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| 2018-0101 |
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