Lenalidomide hemihydrate |CAS 847871-99-2|DC Chemicals

Cas No.:	847871-99-2
Chemical Name:	Lenalidomide hemihydrate
Synonyms:	Lenalidomide (hemihydrate);3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione,hydrate;CC-5013 hemihydrate;CC5013 hemihydrate;Lenalidomide hemihydrate;TS-08295;191732-72-6, anhydride;Q27293963;DA-74946;Lenalidomide hydrate (JAN);(+/-)-2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, hydrate (2:1);(3RS)-3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione hemihydrate;Revlimid (TN);3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;hydrate;Lenalidomide hydrate [JAN];AKOS030526922;XIB87199;Lenalidomide hydrate;SCHEMBL33695;D09813;PD038108;847871-99-2;LENALIDOMIDE HEMIHYDRATE [WHO-DD];3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hemihydrate;(RS)-3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hemihydrate;2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, hydrate (2:1);UNII-XQT0NAW8WD;XQT0NAW8WD;bis(3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione) hydrate
SMILES:	O=C1CCC(N2CC3C(=CC=CC=3N)C2=O)C(=O)N1.O.O=C1CCC(N2CC3C(=CC=CC=3N)C2=O)C(=O)N1
Formula:	C₂₆H₂₈N₆O₇
M.Wt:	536.536525726318
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC67413	MRT-23227
DC67412	MRT-3486
DC67411	MRT-7612
DC67410	MRT-10350
DC67407	IKZF1-degrader-1	IKZF1-degrader-1 (Compound 9-B) is a highly potent molecular glue that achieves sub-nanomolar degradation of IKZF1 (DC50 = 0.134 nM), demonstrating significant therapeutic potential for targeting IKZF1-dependent malignancies.
DC67406	EM12-FS	EM12-FS is a bifunctional CRBN modulator that engages cereblon at His353 while functioning as a molecular glue to induce NTAQ1 degradation. Demonstrating favorable pharmacokinetics, it exhibits a human plasma half-life of 196 minutes, supporting its therapeutic potential.
DC67405	Acetyl-cyclosporin A aldehyde	Acetyl-cyclosporin A aldehyde is a chemically modified derivative of cyclosporin A (HY-B0579), featuring an acetyl group and a reactive aldehyde moiety. The parent compound, cyclosporin A, is a dual-function molecule that both inhibits calmodulin signaling and binds cyclophilin, thereby blocking NF-AT nuclear translocation and inducing mitochondrial dysfunction.
DC67404	QS-57	QS-57 is a bifunctional degrader that combines BRD4-targeting PROTAC activity with 14-3-3 molecular glue properties.
DC67403	KRAS ligand 4	KRAS ligand 4 (compound 2) is a SOS1-targeting bifunctional molecular glue that suppresses oncogenic signaling by degrading key KRAS pathway components, evidenced by reduced pERK and pS6 levels. It demonstrates broad-spectrum activity against diverse KRAS mutations, disrupting proliferation across resistant cancer models.
DC67402	Pomalidomide-15N,13C5	Pomalidomide-15N,13C5 is a stable isotope-labeled variant of pomalidomide (HY-10984), a third-generation immunomodulatory drug that functions as a cereblon-directed molecular glue. This compound mediates targeted ubiquitination and degradation of Ikaros family transcription factors (IKZF1/3) through recruitment of the CRL4CRBN E3 ligase complex, underpinning its therapeutic mechanism.