Doxapram

  Cat. No.:  DC9664   Featured
Chemical Structure
309-29-5
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More than 5000 active chemicals with high quality for research!
Field of application
Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
Cas No.: 309-29-5
Chemical Name: 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one
Synonyms: 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one;1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;Doxapram;Dopram;Doxapram HCL;doxapram hydrochloride;Doxapramum;1-Ethyl-4-(2-morpholin-4-ylethyl)-3,3-di(phenyl)pyrrolidin-2-one
SMILES: O=C1N(CC)CC(CCN2CCOCC2)C1(C3=CC=CC=C3)C4=CC=CC=C4
Formula: C24N2O2H30
M.Wt: 378.5072
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
References: [1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785. [2]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22. [3]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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