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Halopemide

  Cat. No.:  DC28393   Featured
Chemical Structure
59831-65-1
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More than 5000 active chemicals with high quality for research!
Field of application
Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 59831-65-1
Chemical Name: Halopemide
Synonyms: Halopemide;N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide;5-chloro-1-{1-[2-(4-fluoro-benzoylamino)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one;Halopemida;halopemide ( N-<2-<4-(5-chloro-2-oxo-1-benzimidazolinyl)piperidino>ethyl>-p-fluorobenzamide );Halopemidum;N-(2-(4-(5-Chloro-2-oxo-1-benzimidazolinyl)piperidino)ethyl)-p-fluorobenzamide;N-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl-4-fluoro benzamide;R 34,301
SMILES: FC1=CC=C(C(NCCN2CCC(N3C(=O)NC4=CC(=CC=C34)Cl)CC2)=O)C=C1
Formula: C21H22ClFN4O2
M.Wt: 416.876387119293
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent[1][2].
Target: PLD1:220 nM (IC50) PLD2:310 nM (IC50) dopamine receptors
In Vivo: Halopemide (10 mg/kg; p.o.) induces dyskinesias in the majority of monkeys tested[2].
In Vitro: Halopemide (1-2 μM; 21 day) affects calcification in transdifferentiated MOVAS cells[3].
References: [1]. Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. [2]. Neale R, et al. Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride. Psychopharmacology (Berl). 1981;75(3):254-7. [3]. Skafi N, et al. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease. J Cell Physiol. 2019 Apr;234(4):4825-4839.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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