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Trans-4-Phenyl-3-buten-2-one

  Cat. No.:  DC45583   Featured
Chemical Structure
1896-62-4
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More than 5000 active chemicals with high quality for research!
Field of application
Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1896-62-4
Chemical Name: (E)-4-Phenylbut-3-en-2-one
Synonyms: (E)-4-Phenylbut-3-en-2-one;(E)-1-Buten-3-one, 1-phenyl;(e)-3-buten-2-on;Methyl trans-styryl ketone;Tpbo;trans-4-phenyl-but-3-en-2-one;trans-Benzylidenacetone;FEMA 2881;(E)-4-Phenyl-3-buten-2-one;BAR;benzylidene acetone;trans-4-Phenyl-3-but;trans-4-Phenyl-3-buten-2-one;trans-Benzalacetone;2',4',6'-trimethyl-chalcone;2',4',6'-Trimethyl-chalkon;ANILINE,N-BENZYLIDENE-m-NITRO;Benzal-3-nitroaniline;benzalacetomesitylene;Benzal-m-nitroaniline;benzylidene-2,4,6-trimethylacetophenone;mesityl styryl ketone;N-Benzyliden-3-nitro-ani;N-benzylidene-3-nitro-aniline;N-Benzylidene-m-nitroaniline;TC-BAR;WLN: WNR CNU1R;trans-Benzylideneacetone;Methyl trans-Styryl Ketone;BENZALAOETONE;ACETOCINNAMONE;BENZYLIDENACETONE;TRANS-BENZALACETONE;CINNAMYL METHYL KETONE;1-PHENYL-1-BUTEN-3-ONE
SMILES: CC(C=CC1C=CC=CC=1)=O
Formula: C10H10O
M.Wt: 146.185802936554
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant[1].
Target: PLA2
In Vitro: Benzylideneacetone (trans-Benzylideneacetone; 0.005, 0.05, 0.5, 5, 50, 500, 5000 μM) inhibits hemocytespreading behavior of hemocytes of S. exigua larvae. Benzylideneacetone enhances virulence of Bacillus thuringiensisagainst beet armyworm[1].
References: [1]. Kwon B, et al. Benzylideneacetone, an immunosuppressant, enhances virulence of Bacillus thuringiensisagainst beet armyworm (Lepidoptera: Noctuidae). J Econ Entomol. 2008 Feb;101(1):36-41.
MSDS
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MSDS_29310_DC45583
COA
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Cat. No. Product name Field of application
DC71386 (2E)-OBAA (2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM.
DC45583 Trans-4-Phenyl-3-buten-2-one Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
DC43940 Melittin Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
DC28606 MJ33 MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6. MJ33 has a critical effect on inflammatory brain damage.
DC28393 Halopemide Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.
DC7966 U73122 U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).
DC9589 D609 D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent.
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