Kevetrin|cas 66592-89-0|DC Chemicals

Cas No.:	66592-89-0
Chemical Name:	4-Isothioureidobutyronitrile hydrochloride
Synonyms:	3-cyanopropyl carbamimidothioate,hydrochloride;CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1);KEVETRIN, NSC 525990;4-Isothioureidobutyronitrile hydrochloride;Kevetrin hydrochloride;NSC525990;thioureidobutyronitrile hydrochloride;Carbamimidothioic acid 3-cyanopropyl ester hydrochloride;NSC 525990 HCl;Carbamimidothioic acid 3-cyanopropyl ester monohydrochloride;KEVETRIN;Kevetrin Hcl;Kevetrin (hydrochloride);NL6L2371DP;kevetrin-hydrochloride;Thioureidobutyronitrile HCl;Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride;BCP16345;thioureido butyronitrile hydrochloride;AK499423;3-cyanopropyl carbamimidothioate;hydrochloride;A13797;4-(carbamimidoy
SMILES:	Cl[H].S(/C(=N\[H])/N([H])[H])C([H])([H])C([H])([H])C([H])([H])C#N
Formula:	C₅H₁₀ClN₃S
M.Wt:	179.6710
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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Kevetrin HCl